In the same study, diphenhydramine ranked among the top 15 drugs most frequently involved in drug overdose deaths in the U.S. In 2016, a study demonstrated that diphenhydramine overdoses made up 3.2% of drug overdose deaths in the U.S. It is important to note that diphenhydramine can also be found in certain over-the-counter combination medications, such as those used for the treatment of coughs and colds. While intentional diphenhydramine overdose/intoxication can be observed in individuals attempting self-harm/suicide, there is documentation of individuals utilizing diphenhydramine to produce pleasant and euphoric effects. Diphenhydramine overdose or intoxication can be either accidental or intentional. However, it is likely that toxic diphenhydramine exposures are a result of oral ingestion, given the accessibility of oral diphenhydramine compared to other diphenhydramine formulations. Etiologyĭiphenhydramine toxicity can occur via oral, topical, or intravenous administration. Acute intoxications of diphenhydramine can have severe, potentially fatal consequences if not managed appropriately in a timely manner. While used for a wide array of medical indications, diphenhydramine is also one of the most commonly abused medications in the United States (U.S.). It is most commonly used for the treatment of nausea, vomiting, allergic rhinitis, mild to severe allergic reactions (e.g., anaphylaxis), and as a mild sleep aid. Describe interprofessional team strategies for improving care coordination and communication to advance diphenhydramine toxicity management and improve outcomes.ĭiphenhydramine is a first-generation antihistamine with anticholinergic and sedative properties.Outline the management options available for diphenhydramine toxicity.Review the appropriate evaluation of diphenhydramine toxicity.Identify the etiology of diphenhydramine toxicity.This activity describes the evaluation and management of diphenhydramine toxicity and highlights the role of the interprofessional team in managing patients with this condition. To avoid the potentially serious complications and mortality associated with diphenhydramine toxicity, it must be promptly diagnosed and treated. However, due to easy access to this medication, it is often abused and can lead to acute intoxication. Diphenhydramine is most often used for the treatment of nausea, vomiting, allergic rhinitis, mild to severe allergic reactions (e.g., anaphylaxis), and as a mild sleep aid.
0 kommentar(er)
